Despite being the most popular recreationally used drug in the US and Canada, very little is known about how cannabis directly affects the brain. In this study, we are looking at how a synthetic form of cannabis affects the brain’s natural cannabis system and how it relates to behaviour. In order to understand how short term use affects the brain, we will use magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging. One scanning session will take place before the participant takes a one-week course of a cannabis-like drug and the other will happen after.
This study will help further our understanding of how cannabis-like substances interact with the brain, which can help inform the use of cannabis-based medicine for a broad range of medical conditions. It may also help get us closer to understanding the different processes involved in cannabis use disorder. Furthermore, comparing behavioural responses can help better predict how different people will react to cannabis and cannabis-like substances, potentially reducing unwanted side effects.
We are looking for people to participate in this study who:
- Are 19-65 years of age
- Are in good physical and mental health
- Are willing to take a 1-week course of a cannabis-like drug
Participants cannot:
- Have a diagnosis of a mood, anxiety, or substance use disorder
- Regularly use recreational drugs
- Be pregnant or breastfeeding
- Have a known sensitivity to cannabis or cannabis-like drugs
This study has four main components:
- An in-person interview (approx. 4 hours): We will assess your suitability for the study through a series of questionnaires and assessments. You will be required to provide blood and urine samples. If eligible, we will schedule your first scanning session.
- Two brain imaging scanning sessions (approx. 11 hours): You will have two main scanning sessions approx. 3 weeks apart. Scanning session #1 consists of one magnetic resonance imaging (MRI) scan (approx. 1 hour), one positron emission tomography (PET) scan with blood draws (approx. 4 hours) and a few questionnaires to assess mood. Scanning session #2 is identical to Scanning Session #1 without MRI. The purpose of these sessions is to see how FAAH and your mood changes before and after taking the drug.
- A one-week dose of a cannabis-like drug: Between Scanning Session #1 and #2, you will take oral capsules at home for six consecutive days. You will take your 7th and final dose at CAMH 2 hours before your second and final PET scan.
- Virtual check-ins (up to approx. 1.5 hours): While taking the drug, study staff will schedule three virtual meetings with you to see how you feel. We’ll also check-in approx. 2 weeks after your final dose.
The total time commitment for this study is approximately 17.5 hours. You’ll receive compensation for your time. Expenses related to the study sessions such as travel and meals can be reimbursed.