Insulin in the brain has been shown to affect the brain works and processes information (also known as “cognition”). Antipsychotic medications may change the way brain works and processes information as well. We do not know how these changes happen and whether insulin in the brain has anything to do with this. The purpose of this research study is to help find out whether insulin action in the brain has a role in bringing about cognition related effects of antipsychotic medications.
The current study is looking for healthy, right-handed volunteers between the ages of 17 and 45 with no history of type 2 diabetes or psychiatric illness. The study will involve 6 visits, with 4 overnight stays at a hotel, over the course of approximately 3 months. Study procedures will include some questionnaires, physical measures, fasting bloodwork, MRI scans, and cognitive tasks, as well as potentially taking an already approved antipsychotic medication, olanzapine, and insulin which is given by nasal spray.
You will be compensated for your time commitment and participation in the study.
If interested or have any questions about the study, please contact insulin.study@camh.ca or 416-525-8501 ext. 30657. The security of information sent by e-mail cannot be guaranteed. Please do not communicate personal sensitive information by e-mail.
This study is part of REB # 075/2017